{"product_id":"surpass-topical-cream-for-horses-124gm","title":"Surpass Topical Cream for Horses 124gm","description":"\u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:12.0pt;margin-left: 0in;background:white\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10.5pt; font-family: Verdana, sans-serif;\"\u003eSurpass Topical Cream for Horses 124 gram\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:12.0pt;margin-left: 0in;background:white\"\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif;\"\u003eRX Only\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in; background: white; box-sizing: border-box; hyphens: auto;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif;\"\u003ePrescription items are \u003c\/span\u003e\u003cstrong style=\"box-sizing: border-box\"\u003e\u003cspan style='font-size:10.0pt;font-family:\"Verdana\",sans-serif; color:red;border:none windowtext 1.0pt;mso-border-alt:none windowtext 0in; padding:0in'\u003eNON-RETURNABLE\u003c\/span\u003e\u003c\/strong\u003e\u003cspan style='font-size:10.0pt; font-family:\"Verdana\",sans-serif;color:red'\u003e \u003c\/span\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif;\"\u003eand \u003c\/span\u003e\u003cstrong style=\"box-sizing: border-box\"\u003e\u003cspan style='font-size:10.0pt;font-family:\"Verdana\",sans-serif; color:red;border:none windowtext 1.0pt;mso-border-alt:none windowtext 0in; padding:0in'\u003eNON-REFUNDABLE\u003c\/span\u003e\u003c\/strong\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif;\"\u003e\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in; background: white; box-sizing: border-box; hyphens: auto;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif;\"\u003e\u003cstrong\u003eSurpass\u003csup style=\"box-sizing: border-box\"\u003e\u003cspan style=\"border:none windowtext 1.0pt;mso-border-alt:none windowtext 0in; padding:0in\"\u003e™\u003c\/span\u003e\u003c\/sup\u003e\u003c\/strong\u003e Topical Cream is indicated for the control of pain and inflammation associated with osteoarthritis (OA) in tarsal, carpal, metacarpophalangeal, metatarsophalangeal and proximal interphalangeal (hock, knee, fetlock and pastern) joints in horses.\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:12.0pt;margin-left: 0in;background:white\"\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif;\"\u003esage: Apply a five-inch (5\") ribbon of Surpass topical cream twice daily over the affected joint for up to ten days.\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:12.0pt;margin-left: 0in;background:white\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;\"\u003eSurpass\u003c\/span\u003e\u003csup style=\"box-sizing: border-box;\"\u003e\u003cspan style=\"border:none windowtext 1.0pt; mso-border-alt:none windowtext 0in;padding:0in\"\u003e™\u003c\/span\u003e\u003c\/sup\u003e\u003c\/strong\u003e topical cream contains 1% diclofenac sodium. Diclofenac is a non-steroidal anti-inflammatory drug of the phenylacetic acid class. The chemical name for diclofenac is sodium [o- (2,6-dichloroanilino)phenyl]acetate. The empirical formula is C14H10Cl2NNaO2 and the molecular weight is 318.13. Surpass\u003csup style=\"box-sizing: border-box;\"\u003e\u003cspan style=\"border:none windowtext 1.0pt;mso-border-alt: none windowtext 0in;padding:0in\"\u003e™\u003c\/span\u003e\u003c\/sup\u003e topical cream contains 1% diclofenac sodium in a base composed of Phospholipon 90H, propylene glycol, alcohol (5.94%), vitamin E acetate, benzethonium chloride and purified water in the Wisdom\u003csup style=\"box-sizing: border-box;\"\u003e\u003cspan style=\"border:none windowtext 1.0pt;mso-border-alt:none windowtext 0in; padding:0in\"\u003e®\u003c\/span\u003e\u003c\/sup\u003e liposomal formulation.\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif;\"\u003e\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 12pt; background: white; box-sizing: border-box; hyphens: auto;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif;\"\u003e\u003cstrong\u003eAdministration:\u003c\/strong\u003e Wear rubber gloves to prevent absorption into the hands. Rub the cream thoroughly into the hair covering the joint until it disappears.\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin-top:0in;margin-right:0in;margin-bottom:12.0pt;margin-left: 0in;background:white\"\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif;\"\u003eIn a controlled field study, 82 horses with osteoarthritis were treated with \u003cstrong\u003eSurpass™ \u003c\/strong\u003etopical cream (42 horses) or placebo (40 horses). Lameness examinations were performed in horses with osteoarthritis associated with the tarsal, carpal, metacarpophalangeal, metatarsophalangeal and proximal interphalangeal joints. Investigators were masked to treatment. Investigators and owners were instructed to apply the test article over the affected joint twice daily (BID) for five days. Actual doses received by individual horses were calculated using tube weight measurements. The mean dose applied during the study was 73 mg per application. Average lameness scores showed statistically significant improvement following treatment with Surpass topical cream.\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 12pt; background: white; box-sizing: border-box; hyphens: auto;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif;\"\u003eOne diclofenac-treated horse developed colic and responded to symptomatic treatment on day four of the study. Day five bloodwork for the horse that colicked showed decreases in RBC, Hb and HCT, with an increase in PMNs, compared to pretreatment values. One placebo-treated horse exhibited mildly jaundiced mucous membranes on day five. No other adverse reactions were noted during the study.\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in; background: white; box-sizing: border-box; hyphens: auto;\"\u003e\u003cstrong style=\"box-sizing: border-box\"\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif; border: 1pt none windowtext; padding: 0in;\"\u003eAnimal Safety\u003c\/span\u003e\u003c\/strong\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif;\"\u003e\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 12pt; background: white; box-sizing: border-box; hyphens: auto;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif;\"\u003eA controlled safety study was conducted with Surpass topical cream. Four groups of six healthy adult horses received 0, 0.6, 1.7 or 2.8X the recommended daily dose for twenty-eight days. The daily dose was divided into two applications on day one of the study. For the remainder of the study, the entire daily dose was given at one time on 0, 1, 3 or 5 joints (tarsal, carpal, metacarpophalangeal, metatarsophalangeal, and proximal interphalangeal joints), depending on the dosage group. The control group of six horses was sham-dosed by rubbing the joints daily for twenty-eight days. An additional study group evaluated six horses that received 5.6X the recommended daily dose of Surpass topical cream distributed over five joints on a single day. This dose group was observed for fourteen days without additional treatment.\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 12pt; background: white; box-sizing: border-box; hyphens: auto;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif;\"\u003eClinical examinations, hematology, serum chemistry, synovial fluid analyses, gross necropsy and histopathology were performed. At necropsy, one horse in the 5.6X group had a glandular gastric ulcer. A horse in the 2.8X group had diarrhea and uterine discharge throughout the study. Four of the six horses in the 5.6X group lost weight during the study.\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 12pt; background: white; box-sizing: border-box; hyphens: auto;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: Verdana, sans-serif;\"\u003eDose-dependent increases in diclofenac plasma concentrations were detected in horses in the 1.7X and 2.8X treatment groups.\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/p\u003e \u003cp class=\"MsoNormal\"\u003e\u003co:p\u003e \u003c\/o:p\u003e\u003c\/p\u003e","brand":"Boehringer Ingelheim","offers":[{"title":"124 gm","offer_id":46805354938623,"sku":"PX101185","price":84.19,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0709\/1155\/7887\/files\/TPX101185.jpg?v=1745342384","url":"https:\/\/www.countrysupply.com\/products\/surpass-topical-cream-for-horses-124gm","provider":"CountrySupply.com","version":"1.0","type":"link"}