{"product_id":"simplicef","title":"Simplicef","description":"\u003cp\u003e \u003cspan style=\"color:black;font-weight:bold\"\u003ePrescription items are \u003c\/span\u003e \u003cspan style=\"color:red;font-weight:bold;text-decoration: underline;\"\u003eNON-RETURNABLE\u003c\/span\u003e \u003cspan style=\"color:black;font-weight:bold\"\u003e and \u003c\/span\u003e \u003cspan style=\"color:red;font-weight:bold;text-decoration: underline;\"\u003eNON REFUNDABLE\u003c\/span\u003e \u003c\/p\u003e\u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eSimplicef Tablets\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e(cefpodoxime proxetil)\u003cbr\u003e \u003cbr\u003e \u003c\/span\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eSIMPLICEF tablets are indicated for the treatment of skin infections (wounds and abscesses) in dogs caused by susceptible strains of Staphylococcus intermedius Staphylococcus aureus Streptococcus canis (group G B hemolytic) Escherichia coli Pasteurella multocida and Proteus mirabilis.\u003cbr\u003e \u003cbr\u003e \u003c\/span\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eManufacturer:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003ePharmacia Upjohn\u003cbr\u003e \u003cbr\u003e \u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eFor:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eDogs\u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e \u003c\/p\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eDirections for Use:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eUse as Directed by Your Veterinarian\u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e\u003cbr\u003e \u003cstrong\u003eDESCRIPTION:\u003c\/strong\u003e\u003cbr\u003e Cefpodoxime proxetil is an orally administered extended spectrum semi-synthetic cephalosporin antibiotic. The chemical name is: (+\/-)-1-Hydroxyethyl(+)-(6R 7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-3-methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 72-(Z)-(0-methyloxime) isopropyl carbonate (ester) [87239-81-4].\u003cbr\u003e \u003cbr\u003e Cefpodoxime proxetil is a prodrug; its active metabolite is cefpodoxime. All doses of SIMPLICEF (cefpodoxime proxetil) tablets are expressed in terms of the active cefpodoxime moiety. SIMPLICEF is available as:\u003cbr\u003e 100 mg tablet each reddish-orange elliptical scored tablet contains cefpodoxime proxetil equivalent to 100 mg of cefpodoxime.\u003cbr\u003e 200 mg tablet each light orange elliptical tablet contains cefpodoxime proxetil equivalent to 200 mg of cefpodoxime.\u003cbr\u003e \u003cbr\u003e \u003cstrong\u003eCONTRAINDICATIONS\u003cbr\u003e \u003c\/strong\u003eCefpodoxime proxetil is contraindicated in dogs with known allergy to cefpodoxime or to the b-lactam (penicillins and cephalosporins) group of antibiotics.\u003cbr\u003e \u003cbr\u003e \u003cstrong\u003eWARNINGS\u003cbr\u003e \u003c\/strong\u003eNot for human use. Keep this and all drugs out of reach of children. Antimicrobial drugs including penicillins and cephalosporins can cause allergic reactions in sensitized individuals. To minimize the possibility of allergic reactions those handling such antimicrobials including cefpodoxime are advised to avoid direct contact of the product with the skin and mucous membranes.\u003cbr\u003e \u003cbr\u003e \u003cstrong\u003ePRECAUTIONS\u003cbr\u003e \u003c\/strong\u003eThe safety of cefpodoxime proxetil in dogs used for breeding pregnant dogs or lactating bitches has not been demonstrated. As with other cephalosporins cefpodoxime proxetil may occasionally induce a positive direct Coombs' test.\u003cbr\u003e \u003cbr\u003e \u003cstrong\u003eADVERSE REACTIONS\u003cbr\u003e \u003c\/strong\u003eA total of 216 dogs of various breeds and ages ranging from 2 months to 15 years were included in the field study safety analysis. The following table shows the number of dogs displaying each clinical observation.\u003cbr\u003e \u003cbr\u003e \u003cstrong\u003etable 3. Abnormal Health Findings in the U.S. Field Study 1\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e \u003ctable style=\"width: 375pt; border-image: none\" cellpadding=\"0\" width=\"500\" border=\"1\"\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eClinical\u003cbr\u003e Observation\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eSIMPLICEF\u003cbr\u003e (n=118)\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eActive Control\u003cbr\u003e (n=98)\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eVomiting\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e2\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e4\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eDiarrhea: \u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e1\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e1\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eIncreased water drinking\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e0\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e2\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eDecreased appetite\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e1\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e1\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003c\/tbody\u003e \u003c\/table\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e1 Dogs may have experienced more than one of the observations during the study.\u003cbr\u003e \u003cbr\u003e \u003cstrong\u003eCLINICAL PHARMACOLOGY\u003cbr\u003e \u003c\/strong\u003ePharmacokinetics\/Pharmacodynamics: Cefpodoxime proxetil is a prodrug that is absorbed from and de-esterified in the gastrointestinal tract to its active metabolite cefpodoxime. Following oral administration to fasting Beagles oral bioavailability was 63.1 ± 5.3%.\u003cbr\u003e \u003cbr\u003e Cefpodoxime is distributed in the body with an apparent volume of distribution of 151 ± 27 mL\/kg. Like other b-lactam antibiotics cefpodoxime is eliminated from the body primarily in the urine with an apparent elimination half-life of approximately 5-6 hours after oral administration. This is similar to the 4.7 hour apparent elimination half-life observed after intravenous dosing. Following intravenous administration of 10 mg\/kg the average total body clearance (ClB) was 22.7 ± 4.19 mL\/hr\/kg.\u003cbr\u003e \u003cbr\u003e \u003cstrong\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eMicrobiology: \u003cbr\u003e \u003c\/span\u003e\u003c\/strong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eLike other b-lactam antibiotics cefpodoxime exerts its inhibitory effect by interfering with bacterial cell wall synthesis. This interference is primarily due to its covelently binding to the penicillin-binding proteins (PBPs) (i.e. transpeptidase and\/or carboxypeptidase) which are essential for synthesis of the bacterial cell wall. Therefore cefpodoxime is bactericidal. Cefpodoxime is stable in the presence of many common b-lactamese enzymes. As a result many organisms resistant to other b-lactam antibiotics (penicillins and some cephalosporins) due to the production of b-lactamases may be susceptible to cefpodoxime.\u003cbr\u003e Cefpodoxime has a broad spectrum of clinically useful antibacterial activity that includes staphylococci streptococci and Gram-negative species (including Pasteurella Escherichia and Proteus). The compound is not active against most obligate anaerobes Pseudomonas spp. or enterococci. The minimum inhibitory concentrations (MICs) for cefpodoxime against Gram-positive and Gram-negative pathogens isolated from canine skin infections (wounds and abscesses) in a 2002 U.S. field study are presented in table 5. All MICs were determined in accordance with the National Committee for Clinical Laboratory Standards (NCCLS). Appropriate quality control (QC) ranges for in vitro susceptibility testing are presented in table 6.\u003cbr\u003e \u003cbr\u003e \u003cstrong\u003etable 5. Cefpodoxime Minimum Inhibitory Concentration Values (mcg\/mL) from a 2002 Field Study Evaluating Skin Infections (wounds and abscesses) of Canines in the United States.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e \u003ctable style=\"width: 375pt; border-image: none\" cellpadding=\"0\" width=\"500\" border=\"1\"\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eOrganism*\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e# of Isolates\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eMIC50\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eMIC90\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eRange\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eStaphylococcus intermedius\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e118\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e0.12\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e0.50\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e0.12-\u0026gt;32.0\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eStreptococcus canis (group G ß\u003c\/span\u003e\u003c\/em\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e hemolytic)\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e33\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e\u0026lt; or = 0.03\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e\u0026lt; or = 0.03\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e0.03†\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eEscherichia coli\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e41\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e0.25\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e0.50\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e0.12-\u0026gt;32.0\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003ePasteurella multocida\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e32\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e\u0026lt; or = 0.03\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e\u0026lt; or = 0.03\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e\u0026lt; or = 0.03-0.12\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eProteus mirabilis\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e14\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e\u0026lt; or = 0.03\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e0.06\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e\u0026lt; or = 0.03-0.06\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eStaphylococcus aureus\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e19\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e2.0\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e2.0\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e0.12-2.0\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003c\/tbody\u003e \u003c\/table\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e†No Range all isolates yielded the same value.\u003cbr\u003e * Veterinary specific interpretive criteria have not been established for the above listed canine pathogens by the NCCLS atthis time.\u003cbr\u003e \u003cbr\u003e \u003cstrong\u003etable 6. Acceptable Quality Control Ranges for Cefpodoxime\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e \u003ctable style=\"width: 375pt; border-image: none\" cellpadding=\"0\" width=\"500\" border=\"1\"\u003e \u003ctbody\u003e \u003ctr style=\"height: 12.15pt\"\u003e \u003ctd style=\"height: 12.15pt; padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\" rowspan=\"3\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eQC ATCC strain\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"height: 12.15pt; background-color: transparent; border-image: none\" height=\"16\"\u003e\u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\" colspan=\"3\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eKB Disk Diffusion Method\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eBroth Micro-dilution Method\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 10pt\"\u003e \u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e\u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eDrug concentration\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eZone diameter\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eMIC\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 10pt\"\u003e \u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eEscherichia coli \u003c\/span\u003e\u003c\/em\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e25922 \u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e\u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e10 mcg\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e23-28 mma\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e0.25-1 mcg\/mLa\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 10pt\"\u003e \u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eStaphylococcus aureus\u003c\/span\u003e\u003c\/em\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e 25923 \u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e\u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e10 mcg\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e19-25 mma\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e\u003c\/td\u003e \u003ctd style=\"background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 10pt\"\u003e \u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eStaphylococcus aureus \u003c\/span\u003e\u003c\/em\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e29213 \u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e\u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e\u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e\u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e1-8 mcg\/mLa\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 10pt\"\u003e \u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003ctr\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003eStreptococcus pneumoniae \u003c\/span\u003e\u003c\/em\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e49619 \u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e\u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e10 mcg\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e28-34 mmb\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"padding-bottom: 0.75pt; padding-top: 0.75pt; padding-left: 0.75pt; padding-right: 0.75pt; background-color: transparent; border-image: none\"\u003e \u003cp style=\"text-align: center; margin: 0in 0in 0pt; line-height: normal\" align=\"center\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e0.03-0.12 mcg\/mLb\u003c\/span\u003e\u003c\/p\u003e \u003c\/td\u003e \u003ctd style=\"background-color: transparent; border-image: none\"\u003e \u003cp style=\"margin: 0in 0in 10pt\"\u003e \u003c\/p\u003e \u003c\/td\u003e \u003c\/tr\u003e \u003c\/tbody\u003e \u003c\/table\u003e \u003cp style=\"margin: 0in 0in 0pt; line-height: normal\"\u003e\u003cspan style=\"font-size: 10pt; font-family: 'Verdana','sans-serif'\"\u003e\u003cbr\u003e a. These ranges are for quality control strains used to monitor accuracy of minimum inhibitory concentrations (MICs) of non-fastidious organisms using cation-adjusted Mueller-Hinton agar or broth medium. The dilution range should encompass the (IC ranges of these strains in the broth micro-dilution method.\u003cbr\u003e b. These ranges are for quality control strains used to monitor accuracy of minimum inhibitory concentrations (MICs) of fastidious organisms. When susceptibility testing is performed for Streptococcus canis (group G b hemolytic) Streptococcus pneumoniae ATCC 49619 should be included as a QC strain in the presence of 5% lysed sheep blood (KB disk diffusion method) or 2.5% lysed horse blood (broth micro-dilution method).\u003cbr\u003e \u003cbr\u003e \u003cstrong\u003eEFFECTIVENESS:\u003cbr\u003e \u003c\/strong\u003eThe clinical effectiveness of SIMPLICEF (cefpodoxime proxetil) was established in a multi-location (23 site) field study. In this study 216 dogs with infected wounds or abscesses were treated with either SIMPLICEF (n=118) once daily at 5 mg\/kg (2.3 mg\/lb) body weight or with a active control antibiotic (n=98) administered twice daily for 5-7 days. In this study SIMPLICEF was considered noninferior to the active control (88.7% versus 88.4% respectfully) in the treatment of canine skin infections (wounds and abscesses) caused by susceptible strains of Staphylococcus intermedius Staphylococcus aureus Streptococcus canis (group G R hemolytic) Escherichia coli Pasteurella multocida and Proteus mirabilis.\u003cbr\u003e \u003cbr\u003e \u003cstrong\u003eANIMAL SAFETY:\u003cbr\u003e \u003c\/strong\u003eIn target animal safety studies cefpodoxime was well tolerated at exaggerated daily oral doses of 100 mg\/kg\/day (10 times the maximum label dose) for 13 weeks in adult dogs and for 28 days in puppies (18-23 days of age). Therefore once daily administration of cefpodoxime oral tablets at the maximum labeled dose of 10 mg\/kg for up to 28 days was shown to be safe in adult dogs and puppies.\u003cbr\u003e Blood dyscrasia including neutropenias may be seen following high doses of cephalosporins. Cephalosporin administration should be discontinued in such cases.\u003cbr\u003e \u003cbr\u003e \u003cstrong\u003eSTORAGE INformATION:\u003cbr\u003e \u003c\/strong\u003eStore tablets at controlled room temperature 20° to 25°C (68° to 77°F). Replace cap securely after each opening.\u003cbr\u003e \u003cbr\u003e \u003cem\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE.\u003c\/em\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"Simplicef","offers":[{"title":"100mg 1 Tablets","offer_id":46805288911103,"sku":"PX101029 100 001","price":20.41,"currency_code":"USD","in_stock":false},{"title":"100mg 100 Tablets","offer_id":46805288845567,"sku":"PX101029 100 100","price":223.99,"currency_code":"USD","in_stock":false},{"title":"200mg 100 Tablets","offer_id":46805288878335,"sku":"PX101029 200 100","price":431.99,"currency_code":"USD","in_stock":false},{"title":"200mg 1 Tablets","offer_id":46805288943871,"sku":"PX101029 200 001","price":5.59,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0709\/1155\/7887\/files\/T496520.jpg?v=1740100248","url":"https:\/\/www.countrysupply.com\/products\/simplicef","provider":"CountrySupply.com","version":"1.0","type":"link"}