{"product_id":"mexiletine-capsule-200mg-100-count","title":"Mexiletine Capsule 200mg 100 Count","description":"\u003cp\u003e \u003cspan style=\"color:black;font-weight:bold\"\u003ePrescription items are \u003c\/span\u003e \u003cspan style=\"color:red;font-weight:bold;text-decoration: underline;\"\u003eNON-RETURNABLE\u003c\/span\u003e \u003cspan style=\"color:black;font-weight:bold\"\u003e and \u003c\/span\u003e \u003cspan style=\"color:red;font-weight:bold;text-decoration: underline;\"\u003eNON REFUNDABLE\u003c\/span\u003e \u003c\/p\u003e\u003cdiv\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003e\u003cspan id=\"ctl00_ContentPlaceHolder1_ctrItemHeader_lblDesc\" class=\"content11\" style=\"font-weight: bold; color: #000000\"\u003eMexiletine Capsule\u003c\/span\u003e \u003cdiv\u003e \u003c\/div\u003e \u003cdiv\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eMexiletine is a class 1B, sodium channel blocker, anti-arrhythmia drug, used to treat chronic ventricular arrhythmias in the dogs. Mexiletine is used to treat ventricular arrhythmias including PVC’s and ventricular tachycardia. \u003c\/span\u003e\u003c\/span\u003e\u003c\/div\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/div\u003e \u003cdiv\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/div\u003e \u003cdiv\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eMexiletine is well absorbed orally. It is primarily excreted in the urine although approximately 10% is metabolized by the liver and excreted in the feces. The half-life of this drug may be prolonged in animals with reduced cardiac output, or after an acute myocardial infarction. The half-life may also be prolonged in animals with hepatic dysfunction or severe kidney disease.\u003c\/span\u003e\u003c\/span\u003e\u003c\/div\u003e \u003cdiv\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/div\u003e \u003cdiv\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eThe most commonly used oral drugs for the chronic treatment of ventricular arrhythmias are atenolol, sotalol, procainamide, amiodarone, and mexiletine. Mexiletine may be combined with either atenolol or sotalol in instances when monotherapy is not adequate. Mexiletine may be used to treat inherited cardiomyopathy in Boxers and dilated cardiomyopathy in Doberman pinschers. A positive response to therapy would be an 85% reduction of ventricular premature contractions. The complete elimination of ventricular arrhythmia is not considered a realistic goal. \u003c\/span\u003e\u003c\/span\u003e\u003c\/div\u003e \u003cdiv\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003c\/div\u003e \u003cdiv\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eFor Use In:\u003c\/span\u003e\u003c\/span\u003e\u003c\/div\u003e \u003cdiv\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eDogs\u003c\/span\u003e\u003c\/span\u003e\u003c\/div\u003e \u003cdiv\u003e \u003ch3\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eSide Effects\u003c\/span\u003e\u003c\/span\u003e\u003c\/h3\u003e \u003cul\u003e \u003cli\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eThe most common side effects are related to the GI tract including nausea and vomiting. Giving food with mexiletine has been shown to decrease the incidence of GI side effects. \u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e \u003cli\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eOther possible side effects include central nervous system signs such as dizziness, loss of balance and trembling, shortness of breath, and cardiac signs including PVCs or chest pain. \u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e \u003cli\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eRare side effects reported in humans include seizures, and bone marrow suppression. \u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e \u003c\/ul\u003e \u003ch3\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003ePrecautions\u003c\/span\u003e\u003c\/span\u003e\u003c\/h3\u003e \u003cul\u003e \u003cli\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eMexiletine should be used with extreme caution in animals with the following conditions: 2nd or 3rd degree AV heart block, intraventricular conduction abnormality, sinus node function abnormality, cardiogenic shock, congestive heart failure, myocardial infarction, liver dysfunction, hypotension, or seizure disorders. \u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e \u003c\/ul\u003e \u003ch3\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eDrug Interactions \u003c\/span\u003e\u003c\/span\u003e\u003c\/h3\u003e \u003cul\u003e \u003cli\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eConcurrent use with lidocaine increases the likelihood of adverse effects. \u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e \u003cli\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eThere are a number of drugs that may cause drug interactions either through changing the rate of absorption or changing the rate of metabolism of mexiletine. This list includes: antacids, atropine, opiates, cimetidine, griseofulvin, metoclopramide, phenobarbital, phenytoin, primidone, rifampin, theophylline. \u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e \u003cli\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eDrugs which change urinary acidity may affect the renal excretion of mexiletine. These drugs include methionine, ammonium chloride, potassium phosphate, sodium phosphate, citrates, sodium bicarbonate, and carbonic anhydrase inhibitors. \u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e \u003c\/ul\u003e \u003ch3\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eOverdose\u003c\/span\u003e\u003c\/span\u003e\u003c\/h3\u003e \u003cdiv\u003e\u003cspan style=\"font-family: Verdana\"\u003e\u003cspan style=\"font-size: 10pt\"\u003eOverdose with mexiletine carries a significant risk of toxicity. It is reported in the human literature that central nervous system signs precede cardiovascular signs. In experimental work in dogs, a four fold overdose consistently produced CNS signs within 10 minutes of oral administration. If recognized in time, GI emptying protocol should be attempted in conjunction with urinary acidification and supportive care. \u003c\/span\u003e\u003c\/span\u003e\u003c\/div\u003e \u003c\/div\u003e","brand":"Mexiletine","offers":[{"title":"One Size","offer_id":46805358608639,"sku":"P00380","price":119.74,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0709\/1155\/7887\/files\/TP00380.jpg?v=1745342395","url":"https:\/\/www.countrysupply.com\/products\/mexiletine-capsule-200mg-100-count","provider":"CountrySupply.com","version":"1.0","type":"link"}